About the PI

I am a molecular geneticist with a longstanding focus on the biology and genetics of polycystic kidney disease, particularly Autosomal Recessive Polycystic Kidney Disease (ARPKD). My research spans from understanding the molecular and cellular mechanisms that drive disease, to building the genomic and epidemiological tools needed to improve diagnosis and outcomes for patients and families affected by these rare conditions.

I trained at King's College London and the University of Oxford, where I completed my DPhil, before undertaking postdoctoral research at the MRC Mammalian Genetics Unit, Harwell, investigating ciliogenesis and left-right axis asymmetry in mammals.

My lab works at the intersection of genetics, cell biology and translational research. We use molecular, genomic and computational approaches to understand genetic modifiers, characterise disease mechanisms and identify potential therapeutic targets.

My interests in genetics and molecular mechanisms extend beyond kidney disease. During the COVID-19 pandemic, I contributed to work on disease epidemiology and public health strategy, including research advocating for the role of accessible self-testing as a critical tool in pandemic management and the protection of vulnerable communities. More broadly, my lab has explored the molecular basis of growth regulation across biological systems, from investigating the health-relevant phenolic biomolecules in extra virgin olive oil to examining the genetic mechanisms underlying ecological adaptation in marine species to exploring zoonotic diseases.

Beyond the laboratory, I am committed to patient and public engagement, including organising family days for patients and presenting research at public-facing events, writing scientific articles for the lay public and supporting the next generation of researchers through doctoral supervision and early career development schemes.